Методологічне значення інформації для розробки заходів запобігання злочинності в системі інформаційного суспільства

The formation of the information (digital) society of Ukraine is a manifestation of a global trend, the historical inevitability of which is due to the objective logic of civilization. A characteristic feature of these processes is the growing demand for scientific theories, the use of which in practice will ensure social progress and protection of universal values. The purpose of the article is to improve on the basis of a systematic approach to crime prevention measures, the task - to determine the methodological functionality of information for the development of crime prevention measures in the information society. Methodology is rightly considered the theoretical foundation of effective scientific research. At the same time, there is currently no consensus among experts on the content of this category. The definition of methodology as a system of methods of cognition and transformation of reality is offered. It is argued that due to the acceleration of scientific and technological progress and the increase in the amount of information processed, the number of alternative methodological theories will continue to increase significantly. It is pointed out that the fundamental principles of the methodology lie beyond our knowledge and cannot yet be definitively established. Therefore, experts are forced to use methodological concepts, largely based on faith in them. However, each new fact that becomes known to scientists will either confirm or refute substantiate the basic principles of the applied methodology. It is claimed that the information component provides the system functionality of objects and processes in two aspects: 1. Information as a coordinating component of the system (management and one-level coordination). Guidance means providing information to perform mandatory actions. Reconciliation can be defined as the sharing of information to achieve a coordinated outcome. 2. Information as a resource of systemic activity. A resource is an object intended for further processing with a certain result of the system state. In both cases, it is a question of the functionality of the connections between the elements of the system, which understand the interdependence of the existence of phenomena separated in space and time. It is pointed out that in the field of practical activity of the subjects of crime prevention, information is, firstly, a component of coordination processes, and secondly, a resource through which their competence is realized. This is seen in relation to all entities that, in accordance with Art. 2 of the Law of Ukraine "On State Protection of Court Employees and Law Enforcement Bodies" have the status of law enforcement agencies. It is concluded that the system approach as a promising methodology of theory and practice of law enforcement. It is argued that further improvement of crime prevention measures should take into account the information component of systemic activities in this area (information as a resource and coordination component).У статті на засадах системного підходу визначено методологічну функціональність інформації для розробки заходів запобіганні злочинності в системі інформаційного суспільства. Окреслено функціональне значення інформації щодо цивілізаційних процесів взагалі та згаданого методологічного підходу зокрема. Зроблено висновок про значення системного підходу як перспективної методології теорії та практики правоохоронної діяльності. Наголошено, що подальше вдосконалення заходів запобігання злочинності має відбуватися з урахуванням інформаційної складової системної діяльності у цій сфері (інформація як ресурс та координаційна складова)

Методологічне значення інформації для розробки заходів запобігання злочинності в системі інформаційного суспільства

У статті на засадах системного підходу визначено методологічну функціональність інформації для розробки заходів запобіганні злочинності в системі інформаційного суспільства. Окреслено функціональне значення інформації щодо цивілізаційних процесів взагалі та згаданого методологічного підходу зокрема. Зроблено висновок про значення системного підходу як перспективної методології теорії та практики правоохоронної діяльності. Наголошено, що подальше вдосконалення заходів запобігання злочинності має відбуватися з урахуванням інформаційної складової системної діяльності у цій сфері (інформація як ресурс та координаційна складова)

Development of a monoclonal anti-ADAMTS-5 antibody that specifically blocks the interaction with LRP1

The potent aggrecanase ADAMTS-5 is constitutively secreted by chondrocytes, but it is rapidly endocytosed in normal cartilage via the cell surface endocytic receptor LRP1. Therefore it is difficult to detect the total ADAMTS-5 activity produced. In this study, we isolated a monoclonal anti-ADAMTS-5 antibody 1B7 that blocks LRP1-mediated internalization without affecting the aggrecanolytic activity. Addition of 1B7 to cultured human chondrocytes revealed the full aggrecanolytic activity of ADAMTS-5 generated by the cells. 1B7 is a useful tool to estimate the ADAMTS-5 activity and to identify its potential roles in the tissues

Observation of ionospheric Alfven resonance at a middle latitude station

This paper intends to report on the statistical results on the spectral resonance structures of the ionospheric Alfven resonances (IAR) in the ULF frequency range 0.1-5.0 Hz on the basis of the analysis of long-term data obtained from July 2000 to December 2002 (2.5 years) at the Karimshino station (Kamchatka, Russia) (L=2.1) by the conventional 3-component search-coil magnetometer. We analyze both the dynamic spectra of three components and polarization spectra in order to distinguish IAR from other possible noises. The average frequency difference _F between the adjacent maxima, intensity and occurrence rate of the IAR spectra have been estimated from the averaged spectra. Early papers at middle latitudes have been based on a small data base. Based on our first long-term observation at middle latitude, new findings, especially related to the seasonal variation, have emerged from this analysis. (1) There is an evident seasonal variation in the occurrence rate with a maximum in the September-January period and an almost complete absence of IAR structures in the spring-early summer time. (2) Occurrence maximum in the diurnal variation is found at 21-23 LT in the autumn and winter. Almost all the IAR structures are observed at local nighttime. (3) The averaged _F is found to be about 0.2-0.5 Hz in the autumn period but it seems to increase up to 0.5-0.7 Hz in winter. (4) The IAR occurrence rate is inversely correlated with the Kp index of global magnetic activity. (5) The intensity of D component exceeds essentially that of H component of the IAR structures in a majority of cases. Diurnal variations of resonance frequencies in the H and D components are not always identical. Finally the mechanisms to explain the observed characteristics of the IAR have been discussed

Technique and Technology of Whole-Body Cryotherapy (WBC)

Whole-body cryotherapy (WBC) is a highly effective treatment method of a number of serious diseases. The therapeutic effect of WBC is achieved by stimulating cold receptors of the patient’s skin, which provide supercooling of the skin surface to the level of −2°C. To achieve such a temperature of the skin surface, it is necessary to ensure heat removal with intensity not less than 3500 W/m2. Such a heat flux can remove gas with the temperature not higher than −130°C. Procedures lasting less than 2 minutes do not form therapeutic effect. Procedures lasting more than 3 minutes are dangerous for the patient’s health. WBC procedures are carried out in single- and multi-seat devices. Due to the compact placement of the patient in the WBC area, the share of useful heat load on the cryostatting system is up to 70%. In multi-seat installations, the useful heat load share is not more than 50%. During the WBC procedure, consumption of liquid nitrogen per patient is 3.77 kg. For the effective use of WBC technology, it is necessary to determine the general requirements for the power of cooling systems and the temperature of cryostatting of the WBC area

Development of Self-Trigger Algorithms for Radio Detection of Air-Showers

The detection of extensive air-showers with radio method isa relatively young. But promising branch in experimental astrophysics ofultrahigh energies. This method allows one to carry out observations re-gardless of weather conditions and time of day, and the precision of recon-struction of the properties of primary particles is comparable to the clas-sical methods. The main disadvantage of this method is the complexityof the trigger implementation. Radio signals from extensive air-showershave a duration of few tens nanoseconds and amplitudes comparable tothe surrounding background. Moreover, industrial noise, tele- and radiobroadcasting signals, as well as noise from the electronic equipment ofthe experiment, often interfere with measurements. Most of the setupsfor detecting radio emission from extensive air-showers use an externaltrigger from optical or particle detectors. Despite numerous attemptsto develop autonomous (operating with an internal trigger) cosmic rayradio detectors, there is still no established cost-effective technology forthe sparse radio arrays. In the present work, we give an overview of ourprogress in this direction, particularly, we describe a noise generator andsimulation study using data from the Tunka-Rex Virtual Observatory

Efficiency estimation of self-triggered antenna clusters for air-shower detection

Air-shower radio arrays operate in low signal-to-noise ratio conditions, which complicates the autonomous measurement of air-shower signals without using an external trigger from optical or scintillator detectors. A simple threshold trigger for radio detector can be efficiently applied onlyin radio-quiet conditions, because for other cases this trigger detects a high fraction of noise pulses. In the present work, we study aspects of independent air-shower detection by dense antenna clusters with a complex real-time trigger system. For choosing the optimal procedures for the real-time analysis, we study the dependence between trigger efficiency, count rate, detector hardware and geometry. For this study, we develop a framework for testing various methods of signal detection and noise filtration for arrays with various specifications and the hardware implementation of these methods based on field programmable gate arrays. The framework provides flexible settings for the management of station-level and cluster-level steps of detecting the signal, optimized for the hardware implementation for real-time processing. It includes data-processing tools for the initialconfiguration and tests on pre-recorded data, tools for configuring the trigger architecture andtools for preliminary estimates of the trigger efficiency at given thresholds of cosmic-ray energyand air-shower pulse amplitude. We show examples of the trigger pipeline developed with this framework and discuss the results of tests on simulated data